Best midsize gas mileage - 10 cylinder engine

EPA designations: Midsize Cars

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Year Model Engine Trans MPG
2010 Audi S6 5.2L V10 Auto(S6) 16 MPG
2011 Audi S6 5.2L V10 Auto(S6) 16 MPG
2010 BMW M5 5.0L V10 Auto(S7) 13 MPG
2010 BMW M5 5.0L V10 Manual(M6) 13 MPG
 
Mileage data collected from fueleconomy.gov. This website is neither affiliated nor endorsed by the EPA.